In a Phase I clinical trial assessing MGE toxicity, 3 of 18 patients had stable disease for 5 months one patient remains on study after 27 months without tumor progression.Cardiac toxicity induced by Trastuzamab in a mouse model of HER2+ breast cancer was also significantly reduced, suggesting that the extract may be an effective adjuvant to prevent heart damage caused by chemotherapeutics. Further, the extract improved hypertension-induced heart and vessel damage and therefore may prevent end organ damage caused by hypertension.These results indicate that the extract potentially provides an energy boost to cells and thereby may improve physical function. The MGE improved exercise capacity in aged, hypertensive female rats and enhanced the energetic capacity, fitness, and bioenergetics of female rat heart cells.In vitro and in vivo studies show that the MGE prevented damage to muscle and bone caused by a biologically equivalent dose of radiation in the mouse hindlimb, suggesting that the extract could serve as an adjuvant to radiation therapy to prevent radiation damage to normal tissue or as a protective agent to prevent radiation damage to astronauts.MGE increased microbial diversity and altered the microbiome to favor a more beneficial microbial population, suggesting that the extract could be used as a probiotic.MGE attenuated human breast cancer cell migration and tumor metastasis to the lungs and liver in mice, suggesting that the extract may effectively reduce metastasis.Some of the major research findings so far include: The specific type of MGE being studied by Wake Forest Baptist scientists is a new formulation not commercially available that was developed by Piedmont Research Corp.
In addition, the gift supported preclinical studies (animal models) on the treatment of breast cancer with MGE preclinical studies to determine the molecular mechanisms for the reductions in tumor growth the effect of co-administration of the extract with radiation and chemotherapeutics commonly used to treat breast and prostate cancer and more. This five-year gift funded three clinical trials: a Phase I trial to determine toxicity of the extract in patients with solid tumors, and two Phase II trials, one in men with prostate cancer and one in women with triple negative breast cancer, to determine the effect of the extract on reducing metastatic growth and on quality of life issues. The 5-year research study involves 26 faculty members from multiple disciplines, including hypertension and vascular research, hematology and oncology, cancer biology, urology, radiology, public health sciences, radiation biology and pathology. The gift is the largest ever received by the Medical Center. News & World Report’s Best Hospitals.In 2015, Wake Forest Baptist Medical Center received an anonymous $20 million donation to study the effects of a proprietary muscadine grape extract (MGE) on prostate and breast cancers. Our care and treatments have been recognized as High Performing in Neurology and Neurosurgery by U.S. We are proud to have 2 board-certified and fellowship-trained pediatric neurosurgeons on our team that serve our smallest patients at Brenner Children's. We combine the latest treatments and technologies with advanced research and renowned specialty programs to bring you the region’s most comprehensive care for brain, spine and nervous system disorders. Our neurosurgeons also specialize in complex spinal surgeries, surgical management of epilepsy and comprehensive stroke care. We have one of the nation's leading Gamma Knife Centers and are one of the few centers in the country using Deep Brain Stimulation in the treatment of movement disorders, brain tumors, Tourette syndrome and depression. A neurosurgeon may provide either surgical or non-surgical care depending on the nature of the injury or illness.Īt Wake Forest Baptist, many of our neurosurgeons are world-leaders in minimally-invasive techniques and MRI-guided laser surgeries. Neurological surgeons (neurosurgeons) provide diagnosis and treatment to patients with injury to or diseases of, the brain, spine or peripheral nerves.
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